Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-relB/HigB(toxin)
Location 1449442..1449989 Replicon chromosome
Accession NC_017856
Organism Methylophaga frappieri

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Q7C_RS06850 Protein ID WP_041366993.1
Coordinates 1449711..1449989 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag Q7C_RS06845 Protein ID WP_014704000.1
Coordinates 1449442..1449630 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Q7C_RS06805 1444665..1445138 + 474 WP_041366632.1 GNAT family N-acetyltransferase -
Q7C_RS06815 1445706..1446134 + 429 WP_041366635.1 hypothetical protein -
Q7C_RS13610 1446402..1446605 + 204 WP_014703995.1 hypothetical protein -
Q7C_RS06825 1446597..1446866 - 270 WP_014703996.1 hypothetical protein -
Q7C_RS06830 1446894..1447901 - 1008 WP_014703997.1 type IV secretion system protein -
Q7C_RS06835 1447916..1448131 - 216 WP_014703998.1 hypothetical protein -
Q7C_RS06840 1448148..1448867 - 720 WP_014703999.1 P-type DNA transfer protein VirB5 -
Q7C_RS06845 1449442..1449630 + 189 WP_014704000.1 antitoxin of toxin-antitoxin stability system Antitoxin
Q7C_RS06850 1449711..1449989 + 279 WP_041366993.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Q7C_RS06855 1449989..1450327 + 339 WP_014704002.1 HigA family addiction module antidote protein -
Q7C_RS06860 1450347..1450673 + 327 WP_014704003.1 type II toxin-antitoxin system HicB family antitoxin -
Q7C_RS06865 1450687..1451178 + 492 WP_014704004.1 hypothetical protein -
Q7C_RS06870 1451223..1451882 - 660 WP_151194732.1 hypothetical protein -
Q7C_RS06875 1452234..1452743 + 510 WP_151194733.1 hypothetical protein -
Q7C_RS06880 1452771..1453535 + 765 WP_041366996.1 ATP-binding protein -
Q7C_RS06885 1453594..1454904 - 1311 WP_014704007.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1442687..1456079 13392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10506.01 Da        Isoelectric Point: 8.0628

>T27745 WP_041366993.1 NC_017856:1449711-1449989 [Methylophaga frappieri]
MIKSFKHKGLEKFFTTGSTAGIQAKHSAKVRDQLAFLDSATCIEDMDLPSFRLHELKGKLKGKYSITVSGNWRIVFEFID
GDAYIVNYEDYH

Download         Length: 279 bp

>T27745 NC_017856:1449711-1449989 [Methylophaga frappieri]
ATGATTAAGAGCTTCAAACATAAAGGACTTGAGAAGTTTTTCACGACTGGAAGCACAGCCGGTATTCAGGCGAAACACTC
AGCAAAGGTTCGAGATCAACTTGCGTTCTTAGATTCTGCAACCTGTATCGAAGATATGGATTTACCCAGCTTTCGACTGC
ATGAATTAAAGGGCAAGCTTAAAGGAAAGTATTCCATTACTGTTTCAGGGAATTGGCGAATTGTCTTTGAGTTTATAGAT
GGAGACGCTTACATCGTTAATTATGAGGATTATCACTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6866.01 Da        Isoelectric Point: 4.4184

>AT27745 WP_014704000.1 NC_017856:1449442-1449630 [Methylophaga frappieri]
MVVIEQGKGFPVAVLKKNVPVFYAVPAAAYEALIDKLDDMELAQIVHEREGQPSRVITLDEL

Download         Length: 189 bp

>AT27745 NC_017856:1449442-1449630 [Methylophaga frappieri]
ATGGTCGTGATTGAACAGGGCAAAGGCTTTCCTGTCGCTGTACTGAAGAAAAATGTCCCTGTGTTCTACGCTGTACCAGC
GGCAGCATATGAAGCGTTAATAGATAAGCTGGATGATATGGAACTAGCCCAAATTGTCCATGAGCGTGAAGGCCAACCGT
CCAGAGTAATTACACTGGATGAGCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References