Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 927555..928209 Replicon chromosome
Accession NZ_CP122634
Organism Escherichia coli strain ETEC4085

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag QDW62_RS04575 Protein ID WP_000244777.1
Coordinates 927802..928209 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW62_RS04570 Protein ID WP_000354046.1
Coordinates 927555..927821 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW62_RS04545 (922724) 922724..923467 + 744 WP_000951948.1 SDR family oxidoreductase -
QDW62_RS04550 (923524) 923524..924957 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
QDW62_RS04555 (925002) 925002..925313 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
QDW62_RS04560 (925477) 925477..926136 + 660 WP_000250274.1 hemolysin III family protein -
QDW62_RS04565 (926332) 926332..927312 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QDW62_RS04570 (927555) 927555..927821 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW62_RS04575 (927802) 927802..928209 + 408 WP_000244777.1 protein YgfX Toxin
QDW62_RS04580 (928249) 928249..928770 - 522 WP_001055874.1 flavodoxin FldB -
QDW62_RS04585 (928882) 928882..929778 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDW62_RS04590 (929803) 929803..930513 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW62_RS04595 (930519) 930519..932252 + 1734 WP_000813208.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T277442 WP_000244777.1 NZ_CP122634:927802-928209 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277442 WP_000354046.1 NZ_CP122634:927555-927821 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References