Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 804036..805371 | Replicon | chromosome |
| Accession | NZ_CP122634 | ||
| Organism | Escherichia coli strain ETEC4085 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | A0A0K4CDG2 |
| Locus tag | QDW62_RS03920 | Protein ID | WP_001440173.1 |
| Coordinates | 804036..804983 (-) | Length | 316 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A0K6A7X2 |
| Locus tag | QDW62_RS03925 | Protein ID | WP_000208386.1 |
| Coordinates | 804976..805371 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QDW62_RS03890 (799462) | 799462..800025 | + | 564 | WP_001115154.1 | type II secretion system minor pseudopilin GspH | - |
| QDW62_RS03895 (800022) | 800022..800393 | + | 372 | WP_000820113.1 | type II secretion system minor pseudopilin GspI | - |
| QDW62_RS03900 (800390) | 800390..800995 | + | 606 | WP_024168650.1 | type II secretion system minor pseudopilin GspJ | - |
| QDW62_RS03905 (800992) | 800992..801969 | + | 978 | WP_001460058.1 | type II secretion system minor pseudopilin GspK | - |
| QDW62_RS03910 (801966) | 801966..803144 | + | 1179 | WP_000094962.1 | type II secretion system protein GspL | - |
| QDW62_RS03915 (803146) | 803146..803682 | + | 537 | WP_000942783.1 | GspM family type II secretion system protein YghD | - |
| QDW62_RS03920 (804036) | 804036..804983 | - | 948 | WP_001440173.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| QDW62_RS03925 (804976) | 804976..805371 | - | 396 | WP_000208386.1 | DUF6088 family protein | Antitoxin |
| QDW62_RS03930 (805440) | 805440..806285 | - | 846 | WP_001440175.1 | DUF4942 domain-containing protein | - |
| QDW62_RS03935 (806370) | 806370..806567 | - | 198 | WP_000839266.1 | DUF957 domain-containing protein | - |
| QDW62_RS03940 (806585) | 806585..807073 | - | 489 | WP_000761679.1 | DUF5983 family protein | - |
| QDW62_RS03945 (807070) | 807070..807447 | - | 378 | WP_000854719.1 | TA system toxin CbtA family protein | - |
| QDW62_RS03950 (807537) | 807537..807905 | - | 369 | WP_001285113.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| QDW62_RS03955 (807955) | 807955..808599 | - | 645 | WP_000086770.1 | hypothetical protein | - |
| QDW62_RS03960 (808618) | 808618..808839 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
| QDW62_RS03965 (808908) | 808908..809384 | - | 477 | WP_001186715.1 | RadC family protein | - |
| QDW62_RS03970 (809400) | 809400..809885 | - | 486 | WP_000213705.1 | antirestriction protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 316 a.a. Molecular weight: 36284.66 Da Isoelectric Point: 6.2532
>T277440 WP_001440173.1 NZ_CP122634:c804983-804036 [Escherichia coli]
MPELTSLFPDVANALDIESVAIVEKDYFVVNLLKLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRNRKRKIRKEIVQIITDVLHNSDIFSLDNENARITRDEYRYNEIPVRYPQTFAQAPCLRPFIKLELMETTLLEHPESR
DIYSLVTELTGNGTPVTAFPCATILSTQAEKLISMMRRTAILLRNPEQQDDESLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQHPQFRNSPVDELKKGLDALRDDPVHKLRFQRFVKPMVFGNTQIDWEEAYSCFRQTALSVLTN
MPELTSLFPDVANALDIESVAIVEKDYFVVNLLKLLKEIKPETHTLVFAGGTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRNRKRKIRKEIVQIITDVLHNSDIFSLDNENARITRDEYRYNEIPVRYPQTFAQAPCLRPFIKLELMETTLLEHPESR
DIYSLVTELTGNGTPVTAFPCATILSTQAEKLISMMRRTAILLRNPEQQDDESLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQHPQFRNSPVDELKKGLDALRDDPVHKLRFQRFVKPMVFGNTQIDWEEAYSCFRQTALSVLTN
Download Length: 948 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14639.00 Da Isoelectric Point: 11.0607
>AT277440 WP_000208386.1 NZ_CP122634:c805371-804976 [Escherichia coli]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNVITGKIMPAAPGGSAAVITE
ALDRLNIRYSLIGATECYNKGQSTQIPVSPEFKTPPRFKRVLVVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNVITGKIMPAAPGGSAAVITE
ALDRLNIRYSLIGATECYNKGQSTQIPVSPEFKTPPRFKRVLVVGKSKINA
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4CDG2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K6A7X2 |