Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 118815..119440 Replicon plasmid unnamed4
Accession NZ_CP122633
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDW58_RS25430 Protein ID WP_000911333.1
Coordinates 118815..119213 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag QDW58_RS25435 Protein ID WP_000450520.1
Coordinates 119213..119440 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS25415 (115146) 115146..115655 + 510 WP_000628107.1 conjugal transfer entry exclusion protein TraS -
QDW58_RS25420 (115669) 115669..116400 + 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
QDW58_RS25425 (116653) 116653..118806 + 2154 WP_000009325.1 type IV conjugative transfer system coupling protein TraD -
QDW58_RS25430 (118815) 118815..119213 - 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
QDW58_RS25435 (119213) 119213..119440 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..139741 139741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T277436 WP_000911333.1 NZ_CP122633:c119213-118815 [Escherichia coli]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT277436 WP_000450520.1 NZ_CP122633:c119440-119213 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References