Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 25495..26042 Replicon plasmid unnamed4
Accession NZ_CP122633
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDW58_RS24960 Protein ID WP_097309154.1
Coordinates 25764..26042 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QDW58_RS24955 Protein ID WP_000079941.1
Coordinates 25495..25764 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS24935 (20729) 20729..21714 - 986 Protein_19 IS4-like element IS421 family transposase -
QDW58_RS24940 (21715) 21715..22281 - 567 Protein_20 cysteine peptidase family C39 domain-containing protein -
QDW58_RS24945 (22274) 22274..23548 - 1275 WP_000489607.1 HlyD family secretion protein -
QDW58_RS24955 (25495) 25495..25764 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW58_RS24960 (25764) 25764..26042 + 279 WP_097309154.1 type II toxin-antitoxin system toxin YacB Toxin
QDW58_RS24965 (26088) 26088..26936 + 849 WP_001058005.1 3'-5' exonuclease -
QDW58_RS24970 (27053) 27053..27535 + 483 WP_001311056.1 hypothetical protein -
QDW58_RS24975 (27837) 27837..28184 + 348 WP_000142437.1 DUF6404 family protein -
QDW58_RS24980 (28262) 28262..28562 - 301 Protein_28 hypothetical protein -
QDW58_RS24985 (28743) 28743..29684 + 942 WP_263882618.1 3-deoxy-7-phosphoheptulonate synthase -
QDW58_RS24990 (29644) 29644..29778 + 135 WP_249531455.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..139741 139741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10799.42 Da        Isoelectric Point: 8.4615

>T277432 WP_097309154.1 NZ_CP122633:25764-26042 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTVQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT277432 WP_000079941.1 NZ_CP122633:25495-25764 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References