Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 57781..58328 Replicon plasmid unnamed2
Accession NZ_CP122631
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QDW58_RS24470 Protein ID WP_244577696.1
Coordinates 58050..58328 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag QDW58_RS24465 Protein ID WP_000079928.1
Coordinates 57781..58050 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS24440 (53425) 53425..53958 - 534 WP_001303319.1 transcription termination/antitermination NusG family protein -
QDW58_RS24445 (54400) 54400..54687 - 288 WP_000074849.1 conjugal transfer protein TraA -
QDW58_RS24450 (54605) 54605..54883 - 279 WP_219065241.1 ash family protein -
QDW58_RS24455 (55841) 55841..56872 + 1032 WP_000907875.1 plasmid replication initiator RepA -
QDW58_RS24460 (57568) 57568..57726 + 159 WP_000841008.1 hypothetical protein -
QDW58_RS24465 (57781) 57781..58050 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW58_RS24470 (58050) 58050..58328 + 279 WP_244577696.1 type II toxin-antitoxin system toxin YacB Toxin
QDW58_RS24475 (58368) 58368..59216 + 849 WP_001057996.1 3'-5' exonuclease -
QDW58_RS24480 (59453) 59453..59578 - 126 Protein_61 MerR family transcriptional regulator -
QDW58_RS24485 (59573) 59573..61183 + 1611 Protein_62 DDE-type integrase/transposase/recombinase -
QDW58_RS24490 (61186) 61186..62046 + 861 WP_000344784.1 TniB family NTP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ant(3'')-Ia / dfrA1 / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B - 1..110098 110098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10758.39 Da        Isoelectric Point: 8.4615

>T277430 WP_244577696.1 NZ_CP122631:58050-58328 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGPRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT277430 WP_000079928.1 NZ_CP122631:57781-58050 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References