Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4396294..4396889 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QDW58_RS21405 Protein ID WP_000239579.1
Coordinates 4396294..4396644 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QDW58_RS21410 Protein ID WP_001223208.1
Coordinates 4396638..4396889 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS21385 (4391570) 4391570..4392592 - 1023 WP_001296689.1 ABC transporter permease -
QDW58_RS21390 (4392606) 4392606..4394108 - 1503 WP_000205794.1 sugar ABC transporter ATP-binding protein -
QDW58_RS21395 (4394418) 4394418..4395374 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QDW58_RS21400 (4395684) 4395684..4396214 + 531 WP_000055072.1 inorganic diphosphatase -
QDW58_RS21405 (4396294) 4396294..4396644 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QDW58_RS21410 (4396638) 4396638..4396889 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QDW58_RS21415 (4397101) 4397101..4397442 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QDW58_RS21420 (4397445) 4397445..4401215 - 3771 WP_282834280.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T277423 WP_000239579.1 NZ_CP122629:c4396644-4396294 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT277423 WP_001223208.1 NZ_CP122629:c4396889-4396638 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References