Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3732283..3733120 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QDW58_RS18285 Protein ID WP_000227784.1
Coordinates 3732578..3733120 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QDW58_RS18280 Protein ID WP_001297137.1
Coordinates 3732283..3732594 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS18255 (3727303) 3727303..3728250 + 948 WP_098723158.1 cytochrome o ubiquinol oxidase subunit II -
QDW58_RS18260 (3728272) 3728272..3730263 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QDW58_RS18265 (3730253) 3730253..3730867 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QDW58_RS18270 (3730867) 3730867..3731196 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QDW58_RS18275 (3731208) 3731208..3732098 + 891 WP_000971336.1 heme o synthase -
QDW58_RS18280 (3732283) 3732283..3732594 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QDW58_RS18285 (3732578) 3732578..3733120 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QDW58_RS18290 (3733176) 3733176..3734111 - 936 WP_001365761.1 tetratricopeptide repeat protein -
QDW58_RS18295 (3734519) 3734519..3735883 + 1365 WP_001000974.1 MFS transporter -
QDW58_RS18300 (3736011) 3736011..3736502 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QDW58_RS18305 (3736670) 3736670..3737581 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T277421 WP_000227784.1 NZ_CP122629:3732578-3733120 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT277421 WP_001297137.1 NZ_CP122629:3732283-3732594 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References