Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3698206..3698824 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW58_RS18115 Protein ID WP_001291435.1
Coordinates 3698606..3698824 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW58_RS18110 Protein ID WP_000344800.1
Coordinates 3698206..3698580 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS18100 (3693295) 3693295..3694488 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW58_RS18105 (3694511) 3694511..3697660 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDW58_RS18110 (3698206) 3698206..3698580 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW58_RS18115 (3698606) 3698606..3698824 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW58_RS18120 (3698995) 3698995..3699546 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW58_RS18125 (3699662) 3699662..3700132 + 471 WP_000136192.1 YlaC family protein -
QDW58_RS18130 (3700296) 3700296..3701846 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW58_RS18135 (3701888) 3701888..3702241 - 354 WP_000878141.1 DUF1428 family protein -
QDW58_RS18145 (3702620) 3702620..3702931 + 312 WP_000409911.1 MGMT family protein -
QDW58_RS18150 (3702962) 3702962..3703534 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277420 WP_001291435.1 NZ_CP122629:3698606-3698824 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277420 WP_000344800.1 NZ_CP122629:3698206-3698580 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References