Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1010886..1011537 Replicon chromosome
Accession NC_017847
Organism Acinetobacter baumannii MDR-TJ

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag ABTJ_RS04875 Protein ID WP_000838146.1
Coordinates 1010886..1011068 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag ABTJ_RS04880 Protein ID WP_000966689.1
Coordinates 1011133..1011537 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABTJ_RS04830 1006143..1006808 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
ABTJ_RS04835 1006813..1007202 + 390 WP_000008492.1 hypothetical protein -
ABTJ_RS04840 1007204..1007572 + 369 WP_000524231.1 hypothetical protein -
ABTJ_RS04845 1007581..1007985 + 405 WP_000248324.1 hypothetical protein -
ABTJ_RS04850 1007957..1008325 + 369 WP_000539752.1 hypothetical protein -
ABTJ_RS04855 1008327..1008725 + 399 WP_001132270.1 hypothetical protein -
ABTJ_RS04860 1008727..1008939 + 213 WP_000121166.1 hypothetical protein -
ABTJ_RS04865 1009047..1009976 + 930 WP_000094300.1 hypothetical protein -
ABTJ_RS04870 1010021..1010554 + 534 WP_001185622.1 hypothetical protein -
ABTJ_RS04875 1010886..1011068 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
ABTJ_RS04880 1011133..1011537 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ABTJ_RS04885 1011618..1012019 + 402 WP_000720591.1 hypothetical protein -
ABTJ_RS04890 1012080..1016045 + 3966 WP_000191304.1 tape measure protein -
ABTJ_RS04895 1016163..1016504 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 980494..1034187 53693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T27742 WP_000838146.1 NC_017847:1010886-1011068 [Acinetobacter baumannii MDR-TJ]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T27742 NC_017847:1010886-1011068 [Acinetobacter baumannii MDR-TJ]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGACGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
CAAACACCCAACCAAAAAGGGATTAGTAACAATCCCTCATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT27742 WP_000966689.1 NC_017847:1011133-1011537 [Acinetobacter baumannii MDR-TJ]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT27742 NC_017847:1011133-1011537 [Acinetobacter baumannii MDR-TJ]
ATGTTATATCCAATTGCTATTGAAAGAGGTACAGACACCGAAGCCTTTGGTGTCTCCGTTCCAGATATTCCAGGGTGTTT
CAGCGCAGGCGATACATTATATGAAGCTATCGAGAATGTTAAAGAGGCTATTTCTGGCCACTTGGAAATCCTAGCAGAAG
ATGGAGAGGAGATTCCTTTAGCATCTGATGTCAGTAAGTTTATTGACCAAGAAGATTATAGAGGTATGATCTGGGCAGTT
ACTGAAGTTGATGTTAGCCGTTACTTAGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGATTAATTCGGAAGAT
TGATGATAATGTTGGTAAAGATAAAAGATTTAAAACTCGCTCTGCTTTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References