Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2564264..2564902 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDW58_RS12480 Protein ID WP_000813794.1
Coordinates 2564726..2564902 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW58_RS12475 Protein ID WP_001270286.1
Coordinates 2564264..2564680 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS12455 (2559416) 2559416..2560357 - 942 WP_001251315.1 ABC transporter permease -
QDW58_RS12460 (2560358) 2560358..2561371 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDW58_RS12465 (2561389) 2561389..2562534 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QDW58_RS12470 (2562779) 2562779..2564185 - 1407 WP_282834223.1 PLP-dependent aminotransferase family protein -
QDW58_RS12475 (2564264) 2564264..2564680 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW58_RS12480 (2564726) 2564726..2564902 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW58_RS12485 (2565124) 2565124..2565354 + 231 WP_000494244.1 YncJ family protein -
QDW58_RS12490 (2565446) 2565446..2567407 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW58_RS12495 (2567480) 2567480..2568016 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDW58_RS12500 (2568108) 2568108..2569283 + 1176 WP_247187089.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277418 WP_000813794.1 NZ_CP122629:c2564902-2564726 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277418 WP_001270286.1 NZ_CP122629:c2564680-2564264 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References