Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1358195..1358820 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDW58_RS06610 Protein ID WP_000911330.1
Coordinates 1358422..1358820 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QDW58_RS06605 Protein ID WP_000450524.1
Coordinates 1358195..1358422 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS06580 (1353998) 1353998..1354468 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QDW58_RS06585 (1354468) 1354468..1355040 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QDW58_RS06590 (1355186) 1355186..1356064 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QDW58_RS06595 (1356081) 1356081..1357115 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
QDW58_RS06600 (1357328) 1357328..1358041 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QDW58_RS06605 (1358195) 1358195..1358422 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDW58_RS06610 (1358422) 1358422..1358820 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QDW58_RS06615 (1358967) 1358967..1359830 + 864 WP_001267498.1 neutral zinc metallopeptidase -
QDW58_RS06620 (1359845) 1359845..1361860 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
QDW58_RS06625 (1361934) 1361934..1362632 + 699 WP_000679812.1 esterase -
QDW58_RS06630 (1362713) 1362713..1362913 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T277411 WP_000911330.1 NZ_CP122629:1358422-1358820 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT277411 WP_000450524.1 NZ_CP122629:1358195-1358422 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References