Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 268103..268734 Replicon chromosome
Accession NZ_CP122629
Organism Escherichia coli strain ETEC4088

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag QDW58_RS01210 Protein ID WP_001259388.1
Coordinates 268103..268378 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QDW58_RS01215 Protein ID WP_000593555.1
Coordinates 268375..268734 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW58_RS01195 (263107) 263107..264174 + 1068 WP_000361485.1 HlyD family secretion protein -
QDW58_RS01200 (264171) 264171..266906 + 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
QDW58_RS01205 (266906) 266906..268030 + 1125 WP_001314210.1 ABC transporter permease -
QDW58_RS01210 (268103) 268103..268378 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
QDW58_RS01215 (268375) 268375..268734 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDW58_RS01220 (268854) 268854..269255 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QDW58_RS01225 (269261) 269261..270067 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QDW58_RS01230 (270064) 270064..270828 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QDW58_RS01235 (270828) 270828..271661 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
QDW58_RS01240 (271658) 271658..272602 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T277406 WP_001259388.1 NZ_CP122629:268103-268378 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT277406 WP_000593555.1 NZ_CP122629:268375-268734 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References