Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 22333..22925 Replicon plasmid unnamed1
Accession NZ_CP122626
Organism Escherichia coli strain ETEC4089

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag QDW64_RS23460 Protein ID WP_000520549.1
Coordinates 22333..22581 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag QDW64_RS23465 Protein ID WP_000681613.1
Coordinates 22578..22925 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW64_RS23430 (QDW64_23425) 19210..19725 + 516 WP_001025395.1 J domain-containing protein -
QDW64_RS23435 (QDW64_23430) 19830..20372 + 543 WP_001083906.1 hypothetical protein -
QDW64_RS23440 (QDW64_23435) 20369..20620 + 252 WP_001230707.1 hypothetical protein -
QDW64_RS23445 (QDW64_23440) 20607..20834 + 228 WP_000801440.1 hypothetical protein -
QDW64_RS23450 (QDW64_23445) 21288..21587 + 300 WP_000650309.1 hypothetical protein -
QDW64_RS23455 (QDW64_23450) 21678..22028 + 351 WP_000854259.1 hypothetical protein -
QDW64_RS23460 (QDW64_23455) 22333..22581 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
QDW64_RS23465 (QDW64_23460) 22578..22925 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDW64_RS23470 (QDW64_23465) 23286..23789 + 504 WP_089552162.1 relaxosome-coupling protein TaxA -
QDW64_RS23475 (QDW64_23470) 23793..25022 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
QDW64_RS23480 (QDW64_23475) 25099..25365 + 267 WP_000160396.1 hypothetical protein -
QDW64_RS23485 (QDW64_23480) 25370..25603 + 234 WP_000121161.1 EexN family lipoprotein -
QDW64_RS23490 (QDW64_23485) 25959..26579 + 621 WP_000157548.1 lytic transglycosylase domain-containing protein -
QDW64_RS23495 (QDW64_23490) 26593..26919 + 327 WP_000008647.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-2.1 - 1..34703 34703


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T277404 WP_000520549.1 NZ_CP122626:22333-22581 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT277404 WP_000681613.1 NZ_CP122626:22578-22925 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References