Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4026933..4027509 Replicon chromosome
Accession NZ_CP122625
Organism Escherichia coli strain ETEC4089

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDW64_RS19905 Protein ID WP_001297643.1
Coordinates 4027222..4027509 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag QDW64_RS19900 Protein ID WP_000063156.1
Coordinates 4026933..4027235 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW64_RS19885 (4023529) 4023529..4025679 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDW64_RS19890 (4025729) 4025729..4025932 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDW64_RS19895 (4025943) 4025943..4026899 + 957 WP_001297640.1 GTPase -
QDW64_RS19900 (4026933) 4026933..4027235 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
QDW64_RS19905 (4027222) 4027222..4027509 - 288 WP_001297643.1 BrnT family toxin Toxin
QDW64_RS19910 (4027708) 4027708..4028405 - 698 Protein_3892 IS1 family transposase -
QDW64_RS19915 (4028462) 4028462..4028557 + 96 Protein_3893 dienelactone hydrolase family protein -
QDW64_RS19920 (4028703) 4028703..4029935 + 1233 WP_001380906.1 multidrug efflux MFS transporter MdtM -
QDW64_RS19925 (4029976) 4029976..4031256 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277401 WP_001297643.1 NZ_CP122625:c4027509-4027222 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT277401 WP_000063156.1 NZ_CP122625:c4027235-4026933 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References