Detailed information of TA system TA027740

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 2107877..2108469
• Replicon: chromosome
• Accession: NC_017846
• Organism: Aggregatibacter actinomycetemcomitans D7S-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D7S_RS10480
• Protein ID: WP_005542431.1
• Coordinates: 2107877..2108176 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D7S_RS10485
• Protein ID: WP_005542432.1
• Coordinates: 2108173..2108469 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D7S_RS10455	2103153..2104367	-	1215	WP_005542426.1	molybdopterin molybdotransferase MoeA	-
D7S_RS10460	2104496..2105152	+	657	WP_005542427.1	GTP cyclohydrolase I FolE	-
D7S_RS10465	2105253..2106695	-	1443	WP_005542428.1	serine-type D-Ala-D-Ala carboxypeptidase	-
D7S_RS10470	2106855..2107331	+	477	WP_005542429.1	transcription elongation factor GreA	-
D7S_RS10475	2107407..2107709	-	303	WP_005542430.1	ribosome assembly RNA-binding protein YhbY	-
D7S_RS10480	2107877..2108176	+	300	WP_005542431.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D7S_RS10485	2108173..2108469	+	297	WP_005542432.1	putative addiction module antidote protein	Antitoxin
D7S_RS10490	2108502..2109116	-	615	WP_005542433.1	riboflavin synthase	-
D7S_RS10495	2109143..2110540	+	1398	WP_005542434.1	MATE family efflux transporter	-
D7S_RS10500	2110812..2112950	+	2139	WP_005542435.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	lsgD / lsgE / lsgF / kdsA	1948724..2130999	182275

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-90)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11407.47 Da
• Isoelectric Point: 10.4825

>T27740 WP_005542431.1 NC_017846:2107877-2108176 [Aggregatibacter actinomycetemcomitans D7S-1]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Nucleotide

• Length: 300 bp

>T27740 NC_017846:2107877-2108176 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCCAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGATAAA
TCCACTCAAGAGAAAGATATTAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10852.32 Da
• Isoelectric Point: 4.3776

>AT27740 WP_005542432.1 NC_017846:2108173-2108469 [Aggregatibacter actinomycetemcomitans D7S-1]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Nucleotide

• Length: 297 bp

>AT27740 NC_017846:2108173-2108469 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGAGTGAACAATTGAAAAATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAGGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATTGCACGAGCCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTACGCTTCTTAG