Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 2107877..2108469 Replicon chromosome
Accession NC_017846
Organism Aggregatibacter actinomycetemcomitans D7S-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D7S_RS10480 Protein ID WP_005542431.1
Coordinates 2107877..2108176 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D7S_RS10485 Protein ID WP_005542432.1
Coordinates 2108173..2108469 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7S_RS10455 2103153..2104367 - 1215 WP_005542426.1 molybdopterin molybdotransferase MoeA -
D7S_RS10460 2104496..2105152 + 657 WP_005542427.1 GTP cyclohydrolase I FolE -
D7S_RS10465 2105253..2106695 - 1443 WP_005542428.1 serine-type D-Ala-D-Ala carboxypeptidase -
D7S_RS10470 2106855..2107331 + 477 WP_005542429.1 transcription elongation factor GreA -
D7S_RS10475 2107407..2107709 - 303 WP_005542430.1 ribosome assembly RNA-binding protein YhbY -
D7S_RS10480 2107877..2108176 + 300 WP_005542431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D7S_RS10485 2108173..2108469 + 297 WP_005542432.1 putative addiction module antidote protein Antitoxin
D7S_RS10490 2108502..2109116 - 615 WP_005542433.1 riboflavin synthase -
D7S_RS10495 2109143..2110540 + 1398 WP_005542434.1 MATE family efflux transporter -
D7S_RS10500 2110812..2112950 + 2139 WP_005542435.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lsgD / lsgE / lsgF / kdsA 1948724..2130999 182275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11407.47 Da        Isoelectric Point: 10.4825

>T27740 WP_005542431.1 NC_017846:2107877-2108176 [Aggregatibacter actinomycetemcomitans D7S-1]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T27740 NC_017846:2107877-2108176 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCCAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGATAAA
TCCACTCAAGAGAAAGATATTAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10852.32 Da        Isoelectric Point: 4.3776

>AT27740 WP_005542432.1 NC_017846:2108173-2108469 [Aggregatibacter actinomycetemcomitans D7S-1]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT27740 NC_017846:2108173-2108469 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGAGTGAACAATTGAAAAATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAGGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATTGCACGAGCCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTACGCTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References