Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3512322..3512940 Replicon chromosome
Accession NZ_CP122625
Organism Escherichia coli strain ETEC4089

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW64_RS17445 Protein ID WP_001291435.1
Coordinates 3512722..3512940 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW64_RS17440 Protein ID WP_000344800.1
Coordinates 3512322..3512696 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW64_RS17430 (3507411) 3507411..3508604 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW64_RS17435 (3508627) 3508627..3511776 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDW64_RS17440 (3512322) 3512322..3512696 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW64_RS17445 (3512722) 3512722..3512940 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW64_RS17450 (3513112) 3513112..3513663 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW64_RS17455 (3513779) 3513779..3514249 + 471 WP_000136192.1 YlaC family protein -
QDW64_RS17460 (3514413) 3514413..3515963 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW64_RS17465 (3516005) 3516005..3516358 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW64_RS17475 (3516737) 3516737..3517048 + 312 WP_000409911.1 MGMT family protein -
QDW64_RS17480 (3517079) 3517079..3517651 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277399 WP_001291435.1 NZ_CP122625:3512722-3512940 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277399 WP_000344800.1 NZ_CP122625:3512322-3512696 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References