Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2447686..2448324 Replicon chromosome
Accession NZ_CP122625
Organism Escherichia coli strain ETEC4089

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag QDW64_RS12155 Protein ID WP_001447010.1
Coordinates 2448148..2448324 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW64_RS12150 Protein ID WP_001270286.1
Coordinates 2447686..2448102 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW64_RS12130 (2442838) 2442838..2443779 - 942 WP_001251304.1 ABC transporter permease -
QDW64_RS12135 (2443780) 2443780..2444793 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDW64_RS12140 (2444811) 2444811..2445956 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDW64_RS12145 (2446201) 2446201..2447607 - 1407 WP_282833038.1 PLP-dependent aminotransferase family protein -
QDW64_RS12150 (2447686) 2447686..2448102 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW64_RS12155 (2448148) 2448148..2448324 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW64_RS12160 (2448546) 2448546..2448776 + 231 WP_000494244.1 YncJ family protein -
QDW64_RS12165 (2448868) 2448868..2450829 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW64_RS12170 (2450902) 2450902..2451438 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDW64_RS12175 (2451530) 2451530..2452705 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T277398 WP_001447010.1 NZ_CP122625:c2448324-2448148 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277398 WP_001270286.1 NZ_CP122625:c2448102-2447686 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References