Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 22337..22929 Replicon plasmid unnamed4
Accession NZ_CP122624
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag QDW69_RS28405 Protein ID WP_000520549.1
Coordinates 22337..22585 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag QDW69_RS28410 Protein ID WP_000681613.1
Coordinates 22582..22929 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS28375 (QDW69_28375) 19214..19729 + 516 WP_001025395.1 J domain-containing protein -
QDW69_RS28380 (QDW69_28380) 19834..20376 + 543 WP_001083906.1 hypothetical protein -
QDW69_RS28385 (QDW69_28385) 20373..20624 + 252 WP_001230707.1 hypothetical protein -
QDW69_RS28390 (QDW69_28390) 20611..20838 + 228 WP_000801440.1 hypothetical protein -
QDW69_RS28395 (QDW69_28395) 21292..21591 + 300 WP_000650309.1 hypothetical protein -
QDW69_RS28400 (QDW69_28400) 21682..22032 + 351 WP_000854259.1 hypothetical protein -
QDW69_RS28405 (QDW69_28405) 22337..22585 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
QDW69_RS28410 (QDW69_28410) 22582..22929 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDW69_RS28415 (QDW69_28415) 23290..23793 + 504 WP_089552162.1 relaxosome-coupling protein TaxA -
QDW69_RS28420 (QDW69_28420) 23797..25026 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
QDW69_RS28425 (QDW69_28425) 25103..25369 + 267 WP_000160396.1 hypothetical protein -
QDW69_RS28430 (QDW69_28430) 25374..25607 + 234 WP_000121161.1 EexN family lipoprotein -
QDW69_RS28435 (QDW69_28435) 25963..26583 + 621 WP_000157548.1 lytic transglycosylase domain-containing protein -
QDW69_RS28440 (QDW69_28440) 26597..26923 + 327 WP_000008647.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-2.1 - 1..34707 34707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T277384 WP_000520549.1 NZ_CP122624:22337-22585 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT277384 WP_000681613.1 NZ_CP122624:22582-22929 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References