Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 55821..56368 Replicon plasmid unnamed3
Accession NZ_CP122623
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QDW69_RS27925 Protein ID WP_001384452.1
Coordinates 56090..56368 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID K4JYR0
Locus tag QDW69_RS27920 Protein ID WP_000079928.1
Coordinates 55821..56090 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS27895 (51465) 51465..51998 - 534 WP_001303319.1 transcription termination/antitermination NusG family protein -
QDW69_RS27900 (52440) 52440..52727 - 288 WP_000074849.1 conjugal transfer protein TraA -
QDW69_RS27905 (52645) 52645..52923 - 279 WP_219065241.1 ash family protein -
QDW69_RS27910 (53881) 53881..54912 + 1032 WP_000907875.1 plasmid replication initiator RepA -
QDW69_RS27915 (55608) 55608..55766 + 159 WP_000841008.1 hypothetical protein -
QDW69_RS27920 (55821) 55821..56090 + 270 WP_000079928.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW69_RS27925 (56090) 56090..56368 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QDW69_RS27930 (56408) 56408..56560 + 153 Protein_58 3'-5' exonuclease -
QDW69_RS27935 (56749) 56749..57936 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDW69_RS27940 (57936) 57936..58301 - 366 WP_000124098.1 hypothetical protein -
QDW69_RS27945 (58578) 58578..59765 - 1188 WP_000937614.1 IS91-like element IS91 family transposase -
QDW69_RS27950 (59765) 59765..60130 - 366 WP_000124098.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ant(3'')-Ia / dfrA1 / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B - 1..107589 107589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T277382 WP_001384452.1 NZ_CP122623:56090-56368 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10175.50 Da        Isoelectric Point: 7.3210

>AT277382 WP_000079928.1 NZ_CP122623:55821-56090 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLEHGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A5W2J4D0

References