27738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 2078281..2078783 Replicon chromosome
Accession NC_017846
Organism Aggregatibacter actinomycetemcomitans D7S-1

Toxin (Protein)


Gene name relB Uniprot ID A0A5D0ELP0
Locus tag D7S_RS10315 Protein ID WP_005549367.1
Coordinates 2078281..2078535 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relE Uniprot ID A0A5D0ELA5
Locus tag D7S_RS10320 Protein ID WP_005552753.1
Coordinates 2078532..2078783 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7S_RS10300 2074215..2076389 + 2175 WP_014702555.1 DNA helicase II -
D7S_RS10305 2076521..2077348 - 828 WP_005542220.1 DNA ligase -
D7S_RS10310 2077525..2078268 - 744 WP_014702556.1 YdcF family protein -
D7S_RS10315 2078281..2078535 - 255 WP_005549367.1 Txe/YoeB family addiction module toxin Toxin
D7S_RS10320 2078532..2078783 - 252 WP_005552753.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
D7S_RS10325 2078892..2079848 - 957 WP_005542226.1 polysaccharide pyruvyl transferase family protein -
D7S_RS10330 2079845..2081368 - 1524 WP_005542228.1 hypothetical protein -
D7S_RS10335 2081502..2082275 + 774 WP_180267045.1 glycosyltransferase family 25 protein -
D7S_RS10340 2082284..2083474 + 1191 WP_005549375.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - lsgD / lsgE / lsgF / kdsA 1948724..2130999 182275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10203.68 Da        Isoelectric Point: 8.8844

>T27738 WP_005549367.1 NC_017846:c2078535-2078281 [Aggregatibacter actinomycetemcomitans D7S-1]
MILAWTETAWEDYLYWQQVDKKTLVRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>T27738 NC_017846:c2078535-2078281 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGATTTTAGCTTGGACAGAAACCGCCTGGGAAGATTATCTTTATTGGCAGCAAGTTGATAAAAAGACGTTGGTGCGCAT
TAATAAACTTATCCAAAATATTACCAGATCACCTTTCGAAGGCTTAGGCAATCCTGAACCTTTAAAACATCAGTTATCCG
GGTTTTGGTCTAGAAGAATAGATAAAGAGCATCGTCTTGTATACCAAGTATCGGATAGCCATTTAACGATTATTCAATGC
CGCTATCACTACTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9414.65 Da        Isoelectric Point: 5.0637

>AT27738 WP_005552753.1 NC_017846:c2078783-2078532 [Aggregatibacter actinomycetemcomitans D7S-1]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQFNSGKIVERE
LQE

Download         Length: 252 bp

>AT27738 NC_017846:c2078783-2078532 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGAATGTAATAAGTTATTCTGCGTTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGTCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTGTTAGCCTCTATTGACCAGTTCAATTCAGGTAAAATCGTCGAACGGGAA
CTCCAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5D0ELP0

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0ELA5

References