Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 73905..74427 Replicon plasmid unnamed2
Accession NZ_CP122622
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag QDW69_RS27385 Protein ID WP_000220560.1
Coordinates 73905..74186 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QDW69_RS27390 Protein ID WP_000121743.1
Coordinates 74176..74427 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS27350 (69171) 69171..69536 + 366 WP_000124098.1 hypothetical protein -
QDW69_RS27355 (69536) 69536..70723 + 1188 WP_116794643.1 IS91-like element IS91 family transposase -
QDW69_RS27360 (71000) 71000..71365 + 366 WP_000091308.1 hypothetical protein -
QDW69_RS27365 (71365) 71365..72552 + 1188 WP_000937591.1 IS91 family transposase -
QDW69_RS27370 (72941) 72941..73156 - 216 WP_001180116.1 hypothetical protein -
QDW69_RS27375 (73146) 73146..73391 - 246 WP_000356545.1 hypothetical protein -
QDW69_RS27380 (73436) 73436..73759 - 324 WP_001181907.1 hypothetical protein -
QDW69_RS27385 (73905) 73905..74186 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW69_RS27390 (74176) 74176..74427 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QDW69_RS27395 (75661) 75661..76497 + 837 WP_282868244.1 replication initiation protein -
QDW69_RS27400 (76537) 76537..76983 + 447 WP_000057426.1 hypothetical protein -
QDW69_RS27405 (77120) 77120..77476 + 357 WP_000456533.1 DNA distortion polypeptide 3 -
QDW69_RS27410 (77473) 77473..78450 - 978 WP_001269910.1 hypothetical protein -
QDW69_RS27415 (78475) 78475..78756 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyD / hlyB / hlyA / hlyC / estIa 1..120673 120673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11005.83 Da        Isoelectric Point: 10.5938

>T277377 WP_000220560.1 NZ_CP122622:c74186-73905 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRASGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT277377 WP_000121743.1 NZ_CP122622:c74427-74176 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References