Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1..548 Replicon plasmid unnamed2
Accession NZ_CP122622
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag QDW69_RS26900 Protein ID WP_001384452.1
Coordinates 270..548 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag QDW69_RS26895 Protein ID WP_000079941.1
Coordinates 1..270 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS26895 (1) 1..270 + 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
QDW69_RS26900 (270) 270..548 + 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
QDW69_RS26905 (857) 857..1999 + 1143 WP_158649904.1 YiiX/YebB-like N1pC/P60 family cysteine hydrolase -
QDW69_RS26910 (1972) 1972..2076 + 105 Protein_3 hypothetical protein -
QDW69_RS26915 (2088) 2088..2999 + 912 WP_024244186.1 toll/interleukin-1 receptor domain-containing protein -
QDW69_RS26920 (3141) 3141..3536 - 396 WP_000445930.1 plasmid partitioning/stability family protein -
QDW69_RS26925 (3536) 3536..4495 - 960 WP_000921958.1 plasmid segregation protein ParM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyD / hlyB / hlyA / hlyC / estIa 1..120673 120673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T277372 WP_001384452.1 NZ_CP122622:270-548 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT277372 WP_000079941.1 NZ_CP122622:1-270 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References