Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4862620..4863117 Replicon chromosome
Accession NZ_CP122620
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW69_RS24730 Protein ID WP_001173343.1
Coordinates 4862620..4862793 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW69_RS24735 Protein ID WP_000398619.1
Coordinates 4862821..4863117 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS24720 (4859290) 4859290..4860747 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QDW69_RS24725 (4860984) 4860984..4862501 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW69_RS24730 (4862620) 4862620..4862793 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW69_RS24735 (4862821) 4862821..4863117 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW69_RS24740 (4863344) 4863344..4863616 - 273 WP_000405651.1 GNAT family N-acetyltransferase -
QDW69_RS24745 (4863628) 4863628..4863858 - 231 WP_000371704.1 4Fe-4S mono-cluster protein YjdI -
QDW69_RS24750 (4864039) 4864039..4865670 + 1632 WP_001216477.1 sensor histidine kinase -
QDW69_RS24755 (4865667) 4865667..4866386 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4823601..4863117 39516


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277371 WP_001173343.1 NZ_CP122620:c4862793-4862620 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277371 WP_000398619.1 NZ_CP122620:c4863117-4862821 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References