Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4002301..4002919 Replicon chromosome
Accession NZ_CP122620
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW69_RS20390 Protein ID WP_001291435.1
Coordinates 4002701..4002919 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW69_RS20385 Protein ID WP_000344800.1
Coordinates 4002301..4002675 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS20375 (3997390) 3997390..3998583 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW69_RS20380 (3998606) 3998606..4001755 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDW69_RS20385 (4002301) 4002301..4002675 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW69_RS20390 (4002701) 4002701..4002919 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW69_RS20395 (4003091) 4003091..4003642 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW69_RS20400 (4003758) 4003758..4004228 + 471 WP_000136192.1 YlaC family protein -
QDW69_RS20405 (4004392) 4004392..4005942 + 1551 WP_001372457.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW69_RS20410 (4005984) 4005984..4006337 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW69_RS20420 (4006716) 4006716..4007027 + 312 WP_000409911.1 MGMT family protein -
QDW69_RS20425 (4007058) 4007058..4007630 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277367 WP_001291435.1 NZ_CP122620:4002701-4002919 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277367 WP_000344800.1 NZ_CP122620:4002301-4002675 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References