Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 3050105..3050576 Replicon chromosome
Accession NZ_CP122620
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QDW69_RS15540 Protein ID WP_001303511.1
Coordinates 3050298..3050576 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QDW69_RS15535 Protein ID WP_001302048.1
Coordinates 3050105..3050296 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS15495 (3045625) 3045625..3045884 - 260 Protein_3029 DNA-binding protein -
QDW69_RS15500 (3045902) 3045902..3046357 - 456 WP_001151173.1 DUF977 family protein -
QDW69_RS15505 (3046374) 3046374..3047144 - 771 WP_000450698.1 DUF1627 domain-containing protein -
QDW69_RS15510 (3047167) 3047167..3047913 - 747 WP_000788975.1 ATP-binding protein -
QDW69_RS15515 (3047920) 3047920..3048867 - 948 WP_063082131.1 helix-turn-helix domain-containing protein -
QDW69_RS15520 (3048891) 3048891..3049316 - 426 WP_000693861.1 toxin YdaT family protein -
QDW69_RS15525 (3049313) 3049313..3049615 - 303 WP_000172735.1 transcriptional regulator -
QDW69_RS15530 (3049713) 3049713..3050084 + 372 WP_001169685.1 hypothetical protein -
QDW69_RS15535 (3050105) 3050105..3050296 + 192 WP_001302048.1 hypothetical protein Antitoxin
QDW69_RS15540 (3050298) 3050298..3050576 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW69_RS15545 (3050868) 3050868..3051020 + 153 WP_000379558.1 DUF1391 family protein -
QDW69_RS15550 (3051032) 3051032..3051397 + 366 WP_001320327.1 hypothetical protein -
QDW69_RS15555 (3051366) 3051366..3051566 - 201 WP_000159335.1 hypothetical protein -
QDW69_RS15560 (3052069) 3052069..3052257 + 189 WP_000854559.1 cell division inhibition protein DicB -
QDW69_RS15565 (3052254) 3052254..3052445 + 192 WP_001083273.1 lysis protein YdfD -
QDW69_RS15570 (3052539) 3052539..3055010 + 2472 WP_213831716.1 exonuclease -
QDW69_RS15575 (3055072) 3055072..3055341 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2997696..3063596 65900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T277365 WP_001303511.1 NZ_CP122620:3050298-3050576 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT277365 WP_001302048.1 NZ_CP122620:3050105-3050296 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References