Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2521720..2522358 Replicon chromosome
Accession NZ_CP122620
Organism Escherichia coli strain ETEC4090

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDW69_RS12515 Protein ID WP_000813794.1
Coordinates 2522182..2522358 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW69_RS12510 Protein ID WP_001270286.1
Coordinates 2521720..2522136 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW69_RS12490 (2516872) 2516872..2517813 - 942 WP_001251304.1 ABC transporter permease -
QDW69_RS12495 (2517814) 2517814..2518827 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
QDW69_RS12500 (2518845) 2518845..2519990 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
QDW69_RS12505 (2520235) 2520235..2521641 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
QDW69_RS12510 (2521720) 2521720..2522136 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW69_RS12515 (2522182) 2522182..2522358 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW69_RS12520 (2522580) 2522580..2522810 + 231 WP_000494244.1 YncJ family protein -
QDW69_RS12525 (2522902) 2522902..2524863 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW69_RS12530 (2524936) 2524936..2525472 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
QDW69_RS12535 (2525564) 2525564..2526739 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277362 WP_000813794.1 NZ_CP122620:c2522358-2522182 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277362 WP_001270286.1 NZ_CP122620:c2522136-2521720 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References