Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 504520..505054 Replicon chromosome
Accession NC_017846
Organism Aggregatibacter actinomycetemcomitans D7S-1

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag D7S_RS02330 Protein ID WP_005540089.1
Coordinates 504764..505054 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5D0EPW1
Locus tag D7S_RS02325 Protein ID WP_005540091.1
Coordinates 504520..504774 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7S_RS02290 500366..500452 + 87 Protein_432 MerR family DNA-binding transcriptional regulator -
D7S_RS02295 500709..501293 + 585 Protein_433 relaxase/mobilization nuclease domain-containing protein -
D7S_RS02300 501353..502684 + 1332 WP_005594223.1 3-phosphoshikimate 1-carboxyvinyltransferase -
D7S_RS02305 502772..503239 - 468 WP_005540098.1 ribonuclease HI -
D7S_RS02310 503307..504068 + 762 WP_005540094.1 DNA polymerase III subunit epsilon -
D7S_RS02325 504520..504774 + 255 WP_005540091.1 hypothetical protein Antitoxin
D7S_RS02330 504764..505054 + 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D7S_RS02335 505116..505454 - 339 WP_005540087.1 cupin domain-containing protein -
D7S_RS02340 505795..506247 + 453 WP_005540084.1 YeeE/YedE family protein -
D7S_RS02345 506418..507806 + 1389 WP_005540081.1 tRNA 5-hydroxyuridine modification protein YegQ -
D7S_RS02350 508580..509215 + 636 WP_005540076.1 WYL domain-containing protein -
D7S_RS02355 509254..509640 + 387 WP_005540074.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T27736 WP_005540089.1 NC_017846:504764-505054 [Aggregatibacter actinomycetemcomitans D7S-1]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T27736 NC_017846:504764-505054 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGCAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCGGGCGACAAATTAAGAGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCAGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGGAATAGATTAGACGCATATAAAAACGCAGAATTCAGACAAGCTCGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9275.49 Da        Isoelectric Point: 3.9645

>AT27736 WP_005540091.1 NC_017846:504520-504774 [Aggregatibacter actinomycetemcomitans D7S-1]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNHNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT27736 NC_017846:504520-504774 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGGCAATACATCAAATTTTGACACAACAAGCCGCAAGCATTACCGATTTAAAACGGGACCCAATGGGCATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCATAACCAACCAGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTTGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure
AlphaFold DB A0A5D0EPW1

References