Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 468704..469254 Replicon chromosome
Accession NC_017846
Organism Aggregatibacter actinomycetemcomitans D7S-1

Toxin (Protein)


Gene name relE Uniprot ID G4A7B4
Locus tag D7S_RS02145 Protein ID WP_005539226.1
Coordinates 468988..469254 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag D7S_RS02140 Protein ID WP_005539223.1
Coordinates 468704..468976 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7S_RS02100 464580..465221 + 642 WP_005546457.1 sulfite exporter TauE/SafE family protein -
D7S_RS02105 465236..465718 + 483 WP_005552667.1 redoxin family protein -
D7S_RS02110 465850..466044 - 195 WP_005551806.1 integrase core domain-containing protein -
D7S_RS02115 466075..466209 - 135 WP_005544187.1 hypothetical protein -
D7S_RS02120 466216..466419 - 204 WP_005544186.1 IS3 family transposase -
D7S_RS02125 466547..466720 + 174 WP_005552670.1 hypothetical protein -
D7S_RS02130 467096..468448 + 1353 WP_014702284.1 anaerobic C4-dicarboxylate transporter DcuC -
D7S_RS02140 468704..468976 + 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
D7S_RS02145 468988..469254 + 267 WP_005539226.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
D7S_RS02150 469286..470845 + 1560 WP_005539229.1 glutamine-hydrolyzing GMP synthase -
D7S_RS02155 471238..472188 - 951 WP_005539231.1 hypothetical protein -
D7S_RS02160 472382..472795 - 414 WP_005539234.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10502.03 Da        Isoelectric Point: 7.2393

>T27735 WP_005539226.1 NC_017846:468988-469254 [Aggregatibacter actinomycetemcomitans D7S-1]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLVLIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T27735 NC_017846:468988-469254 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCGTTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT27735 WP_005539223.1 NC_017846:468704-468976 [Aggregatibacter actinomycetemcomitans D7S-1]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp

>AT27735 NC_017846:468704-468976 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FY83

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References