277344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 9477..9942 Replicon plasmid unnamed1
Accession NZ_CP122618
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag QDW52_RS23630 Protein ID WP_001230707.1
Coordinates 9477..9728 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag QDW52_RS23635 Protein ID WP_000801440.1
Coordinates 9715..9942 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS23600 (QDW52_23600) 4559..5002 - 444 WP_115769665.1 hypothetical protein -
QDW52_RS23605 (QDW52_23605) 5011..5907 - 897 WP_001122745.1 replication initiation protein -
QDW52_RS23610 (QDW52_23610) 6996..7331 + 336 WP_001147119.1 type II toxin-antitoxin system RelE/ParE family toxin -
QDW52_RS23615 (QDW52_23615) 7328..7678 + 351 WP_000127482.1 addiction module antitoxin -
QDW52_RS23620 (QDW52_23620) 8318..8833 + 516 WP_001025395.1 J domain-containing protein -
QDW52_RS23625 (QDW52_23625) 8938..9480 + 543 WP_001083906.1 hypothetical protein -
QDW52_RS23630 (QDW52_23630) 9477..9728 + 252 WP_001230707.1 hypothetical protein Toxin
QDW52_RS23635 (QDW52_23635) 9715..9942 + 228 WP_000801440.1 hypothetical protein Antitoxin
QDW52_RS23640 (QDW52_23640) 10396..10695 + 300 WP_000650311.1 hypothetical protein -
QDW52_RS23645 (QDW52_23645) 10747..11121 + 375 WP_000844303.1 tail-associated lysozyme -
QDW52_RS23650 (QDW52_23650) 11136..11429 + 294 WP_021568250.1 hypothetical protein -
QDW52_RS23655 (QDW52_23655) 11659..11931 + 273 WP_001363158.1 hypothetical protein -
QDW52_RS23660 (QDW52_23660) 12247..12792 + 546 WP_000815825.1 DNA distortion polypeptide 1 -
QDW52_RS23665 (QDW52_23665) 12795..13961 + 1167 WP_032180641.1 MobP1 family relaxase -
QDW52_RS23670 (QDW52_23670) 14294..14800 + 507 WP_000872474.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..36421 36421


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T277344 WP_001230707.1 NZ_CP122618:9477-9728 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT277344 WP_000801440.1 NZ_CP122618:9715-9942 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References