Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4386222..4386719 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW52_RS21335 Protein ID WP_001173343.1
Coordinates 4386222..4386395 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW52_RS21340 Protein ID WP_000398619.1
Coordinates 4386423..4386719 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS21325 (4382892) 4382892..4384349 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
QDW52_RS21330 (4384586) 4384586..4386103 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW52_RS21335 (4386222) 4386222..4386395 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW52_RS21340 (4386423) 4386423..4386719 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW52_RS21345 (4386946) 4386946..4387218 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDW52_RS21350 (4387230) 4387230..4387460 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
QDW52_RS21355 (4387641) 4387641..4389272 + 1632 WP_001216461.1 sensor histidine kinase -
QDW52_RS21360 (4389269) 4389269..4389988 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277342 WP_001173343.1 NZ_CP122617:c4386395-4386222 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277342 WP_000398619.1 NZ_CP122617:c4386719-4386423 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References