Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4283707..4284302 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QDW52_RS20820 Protein ID WP_000239579.1
Coordinates 4283707..4284057 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QDW52_RS20825 Protein ID WP_001223208.1
Coordinates 4284051..4284302 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS20800 (4278983) 4278983..4280005 - 1023 WP_001339490.1 ABC transporter permease -
QDW52_RS20805 (4280019) 4280019..4281521 - 1503 WP_021548597.1 sugar ABC transporter ATP-binding protein -
QDW52_RS20810 (4281831) 4281831..4282787 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QDW52_RS20815 (4283097) 4283097..4283627 + 531 WP_000055072.1 inorganic diphosphatase -
QDW52_RS20820 (4283707) 4283707..4284057 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QDW52_RS20825 (4284051) 4284051..4284302 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QDW52_RS20830 (4284515) 4284515..4284856 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QDW52_RS20835 (4284859) 4284859..4288638 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T277341 WP_000239579.1 NZ_CP122617:c4284057-4283707 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT277341 WP_001223208.1 NZ_CP122617:c4284302-4284051 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References