277340

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4164096..4164910 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag QDW52_RS20210 Protein ID WP_001054376.1
Coordinates 4164096..4164353 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag QDW52_RS20215 Protein ID WP_001309181.1
Coordinates 4164365..4164910 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS20185 (4159384) 4159384..4160490 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
QDW52_RS20190 (4160555) 4160555..4161535 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
QDW52_RS20195 (4161645) 4161645..4161850 + 206 Protein_3950 HNH endonuclease -
QDW52_RS20200 (4162118) 4162118..4163358 - 1241 Protein_3951 helicase YjhR -
QDW52_RS20205 (4163474) 4163474..4163605 + 132 WP_001309182.1 hypothetical protein -
QDW52_RS20210 (4164096) 4164096..4164353 + 258 WP_001054376.1 YjhX family toxin Toxin
QDW52_RS20215 (4164365) 4164365..4164910 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
QDW52_RS20220 (4164966) 4164966..4165712 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
QDW52_RS20225 (4165881) 4165881..4166099 + 219 Protein_3956 hypothetical protein -
QDW52_RS20230 (4166137) 4166137..4166253 + 117 Protein_3957 VOC family protein -
QDW52_RS20235 (4166498) 4166498..4167619 + 1122 WP_000010829.1 M42 family metallopeptidase -
QDW52_RS20240 (4167616) 4167616..4167894 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
QDW52_RS20245 (4167906) 4167906..4169219 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4153882..4180600 26718


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T277340 WP_001054376.1 NZ_CP122617:4164096-4164353 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT277340 WP_001309181.1 NZ_CP122617:4164365-4164910 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References