277338

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3566073..3566910 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QDW52_RS17480 Protein ID WP_000227784.1
Coordinates 3566368..3566910 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QDW52_RS17475 Protein ID WP_001297137.1
Coordinates 3566073..3566384 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS17450 (3561093) 3561093..3562040 + 948 WP_021548571.1 cytochrome o ubiquinol oxidase subunit II -
QDW52_RS17455 (3562062) 3562062..3564053 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QDW52_RS17460 (3564043) 3564043..3564657 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QDW52_RS17465 (3564657) 3564657..3564986 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QDW52_RS17470 (3564998) 3564998..3565888 + 891 WP_000971336.1 heme o synthase -
QDW52_RS17475 (3566073) 3566073..3566384 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QDW52_RS17480 (3566368) 3566368..3566910 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QDW52_RS17485 (3566966) 3566966..3567901 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QDW52_RS17490 (3568309) 3568309..3569673 + 1365 WP_001000978.1 MFS transporter -
QDW52_RS17495 (3569801) 3569801..3570292 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QDW52_RS17500 (3570460) 3570460..3571371 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T277338 WP_000227784.1 NZ_CP122617:3566368-3566910 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT277338 WP_001297137.1 NZ_CP122617:3566073-3566384 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References