Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2433244..2433882 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDW52_RS11735 Protein ID WP_000813794.1
Coordinates 2433706..2433882 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW52_RS11730 Protein ID WP_001270286.1
Coordinates 2433244..2433660 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS11705 (2428561) 2428561..2429214 - 654 Protein_2288 ABC transporter ATP-binding protein -
QDW52_RS11715 (2429983) 2429983..2430351 - 369 Protein_2290 ABC transporter ATP-binding protein -
QDW52_RS11720 (2430369) 2430369..2431514 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
QDW52_RS11725 (2431759) 2431759..2433165 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
QDW52_RS11730 (2433244) 2433244..2433660 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW52_RS11735 (2433706) 2433706..2433882 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW52_RS11740 (2434104) 2434104..2434334 + 231 WP_000494244.1 YncJ family protein -
QDW52_RS11745 (2434426) 2434426..2436387 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW52_RS11750 (2436460) 2436460..2436996 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
QDW52_RS11755 (2437088) 2437088..2438263 + 1176 WP_001236319.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277335 WP_000813794.1 NZ_CP122617:c2433882-2433706 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277335 WP_001270286.1 NZ_CP122617:c2433660-2433244 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References