277334

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2337056..2338644 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name hipA Uniprot ID U9XU38
Locus tag QDW52_RS11330 Protein ID WP_001125455.1
Coordinates 2337322..2338644 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDW52_RS11325 Protein ID WP_001296726.1
Coordinates 2337056..2337322 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS11325 (2337056) 2337056..2337322 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDW52_RS11330 (2337322) 2337322..2338644 + 1323 WP_001125455.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDW52_RS11335 (2338956) 2338956..2339164 + 209 Protein_2214 AraC family transcriptional regulator -
QDW52_RS11340 (2339598) 2339598..2340161 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
QDW52_RS11345 (2340522) 2340522..2341232 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49321.93 Da        Isoelectric Point: 8.8753

>T277334 WP_001125455.1 NZ_CP122617:2337322-2338644 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277334 WP_001296726.1 NZ_CP122617:2337056-2337322 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XU38

Antitoxin

Source ID Structure

References