Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 100533..101130 Replicon chromosome
Accession NC_017846
Organism Aggregatibacter actinomycetemcomitans D7S-1

Toxin (Protein)


Gene name relE Uniprot ID A0A142FXE8
Locus tag D7S_RS00445 Protein ID WP_005595366.1
Coordinates 100533..100835 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID G4A710
Locus tag D7S_RS00450 Protein ID WP_005556438.1
Coordinates 100837..101130 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D7S_RS00420 95891..96640 - 750 WP_005538836.1 hypothetical protein -
D7S_RS00425 96644..96856 - 213 WP_005538838.1 hypothetical protein -
D7S_RS00430 96991..97227 - 237 WP_005538841.1 hypothetical protein -
D7S_RS11795 97182..98393 - 1212 WP_050856694.1 hypothetical protein -
D7S_RS00440 98434..100380 - 1947 WP_005538140.1 ABC transporter ATP-binding protein -
D7S_RS00445 100533..100835 + 303 WP_005595366.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
D7S_RS00450 100837..101130 + 294 WP_005556438.1 putative addiction module antidote protein Antitoxin
D7S_RS00455 101167..102519 - 1353 WP_005538151.1 deoxyguanosinetriphosphate triphosphohydrolase family protein -
D7S_RS00460 102521..103213 - 693 WP_005538152.1 CidB/LrgB family autolysis modulator -
D7S_RS00465 103213..103623 - 411 WP_005538154.1 CidA/LrgA family protein -
D7S_RS00475 104199..105200 + 1002 WP_005538156.1 site-specific integrase -
D7S_RS00480 105263..105549 - 287 Protein_92 DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 100533..108873 8340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11413.93 Da        Isoelectric Point: 5.8716

>T27733 WP_005595366.1 NC_017846:100533-100835 [Aggregatibacter actinomycetemcomitans D7S-1]
MYIIEETEEFSNWLENLTDELAIVNIVARIERAKLGNFGDHKSVGNGVYEMRITKGKGYRIYYARKGGITYLLILGGDKS
SQEQDIQNAKALWQQIKNGE

Download         Length: 303 bp

>T27733 NC_017846:100533-100835 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGTATATAATTGAGGAAACGGAGGAATTCTCCAACTGGTTAGAGAATCTAACCGACGAACTTGCGATTGTGAATATTGT
TGCTCGAATCGAAAGGGCAAAGCTCGGCAATTTCGGTGATCATAAATCGGTGGGTAATGGCGTATATGAAATGCGAATTA
CAAAAGGGAAAGGCTATAGGATCTACTATGCCAGAAAAGGGGGTATTACTTATCTATTGATTCTTGGTGGCGATAAGTCA
AGCCAAGAACAAGATATTCAGAATGCAAAAGCACTATGGCAACAGATTAAAAACGGAGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10694.39 Da        Isoelectric Point: 6.3545

>AT27733 WP_005556438.1 NC_017846:100837-101130 [Aggregatibacter actinomycetemcomitans D7S-1]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Download         Length: 294 bp

>AT27733 NC_017846:100837-101130 [Aggregatibacter actinomycetemcomitans D7S-1]
ATGACAGTAACAACCCGAGAATTTGATGCAGCGCGTTATTTGAAAAATGAAAAAATGATGGCAATGTATCTTGAAACAGT
TTTAGAAGAAGGCACAACGGCTGAGTTTATACAAGCTCTGAATACGGTCGCAAGAGCAAAGGGCATGTCGGAACTGGCGG
AAAAAACCGGCATCGGACGTGAAAGTTTGTACAAAACCCTATCAAGTGAAAAACCACGTTTTGACACGATTCTAAAAATT
ATTTCAGCATTGGGGCTTAGCCTTTCTATTAATGCTAAAGATGCAGTAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FXE8

Antitoxin

Source ID Structure
AlphaFold DB A0A142FXE9

References