Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1285514..1286139 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDW52_RS06245 Protein ID WP_000911330.1
Coordinates 1285741..1286139 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QDW52_RS06240 Protein ID WP_000450524.1
Coordinates 1285514..1285741 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS06215 (1281317) 1281317..1281787 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QDW52_RS06220 (1281787) 1281787..1282359 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QDW52_RS06225 (1282505) 1282505..1283383 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QDW52_RS06230 (1283400) 1283400..1284434 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QDW52_RS06235 (1284647) 1284647..1285360 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QDW52_RS06240 (1285514) 1285514..1285741 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QDW52_RS06245 (1285741) 1285741..1286139 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QDW52_RS06250 (1286286) 1286286..1287149 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QDW52_RS06255 (1287164) 1287164..1289179 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QDW52_RS06260 (1289253) 1289253..1289951 + 699 WP_000679823.1 esterase -
QDW52_RS06265 (1290061) 1290061..1290261 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T277327 WP_000911330.1 NZ_CP122617:1285741-1286139 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT277327 WP_000450524.1 NZ_CP122617:1285514-1285741 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References