277326

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 994496..995079 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QDW52_RS04820 Protein ID WP_021548855.1
Coordinates 994744..995079 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S1P3W5
Locus tag QDW52_RS04815 Protein ID WP_000581937.1
Coordinates 994496..994744 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS04805 (990835) 990835..992136 + 1302 WP_000046790.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
QDW52_RS04810 (992184) 992184..994418 + 2235 WP_000226815.1 GTP pyrophosphokinase -
QDW52_RS04815 (994496) 994496..994744 + 249 WP_000581937.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QDW52_RS04820 (994744) 994744..995079 + 336 WP_021548855.1 endoribonuclease MazF Toxin
QDW52_RS04825 (995150) 995150..995941 + 792 WP_001071648.1 nucleoside triphosphate pyrophosphohydrolase -
QDW52_RS04830 (996169) 996169..997806 + 1638 WP_000210878.1 CTP synthase (glutamine hydrolyzing) -
QDW52_RS04835 (997894) 997894..999192 + 1299 WP_000036723.1 phosphopyruvate hydratase -
QDW52_RS04840 (999248) 999248..999610 - 363 WP_000034929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-109)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12186.13 Da        Isoelectric Point: 8.4777

>T277326 WP_021548855.1 NZ_CP122617:994744-995079 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPVVVLSPFMYNNKTGMCLCVPYTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Download         Length: 336 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9355.74 Da        Isoelectric Point: 4.4665

>AT277326 WP_000581937.1 NZ_CP122617:994496-994744 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LMB4

References