Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 858165..858819 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag QDW52_RS04205 Protein ID WP_000244772.1
Coordinates 858412..858819 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QDW52_RS04200 Protein ID WP_000354046.1
Coordinates 858165..858431 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS04175 (853453) 853453..854196 + 744 WP_000951964.1 SDR family oxidoreductase -
QDW52_RS04180 (854253) 854253..855686 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
QDW52_RS04185 (855731) 855731..856042 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
QDW52_RS04190 (856206) 856206..856865 + 660 WP_000250274.1 hemolysin III family protein -
QDW52_RS04195 (856942) 856942..857922 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
QDW52_RS04200 (858165) 858165..858431 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QDW52_RS04205 (858412) 858412..858819 + 408 WP_000244772.1 protein YgfX Toxin
QDW52_RS04210 (858859) 858859..859380 - 522 WP_001055874.1 flavodoxin FldB -
QDW52_RS04215 (859492) 859492..860388 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QDW52_RS04220 (860413) 860413..861123 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDW52_RS04225 (861129) 861129..862862 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T277325 WP_000244772.1 NZ_CP122617:858412-858819 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT277325 WP_000354046.1 NZ_CP122617:858165-858431 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References