277323

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 286275..287075 Replicon chromosome
Accession NZ_CP122617
Organism Escherichia coli strain ETEC4091

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag QDW52_RS01305 Protein ID WP_000342449.1
Coordinates 286548..287075 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag QDW52_RS01300 Protein ID WP_001277108.1
Coordinates 286275..286541 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW52_RS01280 (281933) 281933..282601 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
QDW52_RS01285 (282594) 282594..283652 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
QDW52_RS01290 (283897) 283897..284751 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
QDW52_RS01295 (285022) 285022..286125 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
QDW52_RS01300 (286275) 286275..286541 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
QDW52_RS01305 (286548) 286548..287075 + 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
QDW52_RS01310 (287072) 287072..287455 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
QDW52_RS01315 (287879) 287879..288988 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
QDW52_RS01320 (289036) 289036..289962 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
QDW52_RS01325 (289959) 289959..291236 + 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
QDW52_RS01330 (291233) 291233..292000 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T277323 WP_000342449.1 NZ_CP122617:286548-287075 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT277323 WP_001277108.1 NZ_CP122617:286275-286541 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A829CN24

References