Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4601371..4601868 Replicon chromosome
Accession NZ_CP122604
Organism Escherichia coli strain ETEC6334

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDW51_RS22720 Protein ID WP_001173343.1
Coordinates 4601371..4601544 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDW51_RS22725 Protein ID WP_000398619.1
Coordinates 4601572..4601868 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW51_RS22710 (4598041) 4598041..4599498 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
QDW51_RS22715 (4599735) 4599735..4601252 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDW51_RS22720 (4601371) 4601371..4601544 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDW51_RS22725 (4601572) 4601572..4601868 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDW51_RS22730 (4602095) 4602095..4602367 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDW51_RS22735 (4602379) 4602379..4602609 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QDW51_RS22740 (4602789) 4602789..4604420 + 1632 WP_001216482.1 sensor histidine kinase -
QDW51_RS22745 (4604417) 4604417..4605136 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4558014..4601868 43854


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277317 WP_001173343.1 NZ_CP122604:c4601544-4601371 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277317 WP_000398619.1 NZ_CP122604:c4601868-4601572 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References