Detailed information of TA system TA277313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3950343..3952032
• Replicon: chromosome
• Accession: NZ_CP122604
• Organism: Escherichia coli strain ETEC6334

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A3A6SPN4
• Locus tag: QDW51_RS19380
• Protein ID: WP_063085362.1
• Coordinates: 3950343..3951263 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: QDW51_RS19385
• Protein ID: WP_063502601.1
• Coordinates: 3951250..3952032 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QDW51_RS19365 (3946433)	3946433..3947560	-	1128	WP_042028035.1	MFS transporter	-
QDW51_RS19370 (3947702)	3947702..3948760	-	1059	WP_122987789.1	alpha/beta hydrolase	-
QDW51_RS19375 (3949025)	3949025..3949909	+	885	WP_001119037.1	LysR family transcriptional regulator	-
QDW51_RS19380 (3950343)	3950343..3951263	-	921	WP_063085362.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QDW51_RS19385 (3951250)	3951250..3952032	-	783	WP_063502601.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
QDW51_RS19390 (3952316)	3952316..3955414	+	3099	WP_063085364.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-261)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34587.06 Da
• Isoelectric Point: 7.3238

>T277313 WP_063085362.1 NZ_CP122604:c3951263-3950343 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDIERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29094.32 Da
• Isoelectric Point: 8.1223

>AT277313 WP_063502601.1 NZ_CP122604:c3952032-3951250 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGRPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSLTTELKIGDCQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSVKTNRVMLYLARRNGHPYFQYIDQSGIETGTGKRQIIPGGWLEP
DYQITVPRAFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A3A6SPN4