Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3747312..3747930 Replicon chromosome
Accession NZ_CP122604
Organism Escherichia coli strain ETEC6334

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDW51_RS18445 Protein ID WP_001291435.1
Coordinates 3747712..3747930 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDW51_RS18440 Protein ID WP_000344800.1
Coordinates 3747312..3747686 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW51_RS18430 (3742401) 3742401..3743594 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDW51_RS18435 (3743617) 3743617..3746766 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
QDW51_RS18440 (3747312) 3747312..3747686 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDW51_RS18445 (3747712) 3747712..3747930 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDW51_RS18450 (3748102) 3748102..3748653 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDW51_RS18455 (3748769) 3748769..3749239 + 471 WP_063085325.1 YlaC family protein -
QDW51_RS18460 (3749403) 3749403..3750953 + 1551 WP_063085326.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDW51_RS18465 (3750995) 3750995..3751348 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDW51_RS18475 (3751727) 3751727..3752038 + 312 WP_000409911.1 MGMT family protein -
QDW51_RS18480 (3752069) 3752069..3752641 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277312 WP_001291435.1 NZ_CP122604:3747712-3747930 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277312 WP_000344800.1 NZ_CP122604:3747312-3747686 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References