Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3314689..3315394 Replicon chromosome
Accession NZ_CP122604
Organism Escherichia coli strain ETEC6334

Toxin (Protein)


Gene name relE Uniprot ID A0A3A6SJV3
Locus tag QDW51_RS16425 Protein ID WP_063085620.1
Coordinates 3314689..3315075 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QDW51_RS16430 Protein ID WP_219804798.1
Coordinates 3315065..3315394 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW51_RS16405 (3310693) 3310693..3311319 + 627 WP_001314584.1 glutathione S-transferase GstB -
QDW51_RS16410 (3311316) 3311316..3312431 - 1116 WP_063085618.1 aldose sugar dehydrogenase YliI -
QDW51_RS16415 (3312542) 3312542..3312925 - 384 WP_000497137.1 biofilm formation regulator BssR -
QDW51_RS16420 (3313138) 3313138..3314463 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
QDW51_RS16425 (3314689) 3314689..3315075 + 387 WP_063085620.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDW51_RS16430 (3315065) 3315065..3315394 + 330 WP_219804798.1 DNA-binding transcriptional regulator Antitoxin
QDW51_RS16435 (3315464) 3315464..3316792 - 1329 WP_000086873.1 GGDEF domain-containing protein -
QDW51_RS16440 (3316800) 3316800..3319148 - 2349 WP_021523051.1 EAL domain-containing protein -
QDW51_RS16445 (3319326) 3319326..3320237 - 912 WP_001236019.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14280.45 Da        Isoelectric Point: 9.9296

>T277311 WP_063085620.1 NZ_CP122604:3314689-3315075 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSTKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11964.04 Da        Isoelectric Point: 10.0101

>AT277311 WP_219804798.1 NZ_CP122604:3315065-3315394 [Escherichia coli]
MSDKLQMMLEDAKELNALGLISDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6SJV3

Antitoxin

Source ID Structure

References