Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3491002..3491629 Replicon chromosome
Accession NC_017845
Organism Pectobacterium sp. SCC3193

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag W5S_RS15745 Protein ID WP_005976087.1
Coordinates 3491426..3491629 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag W5S_RS15740 Protein ID WP_005976089.1
Coordinates 3491002..3491370 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W5S_RS15730 3486472..3489600 + 3129 WP_014700817.1 multidrug efflux RND transporter permease subunit -
W5S_RS15735 3489834..3490082 + 249 WP_014700818.1 type B 50S ribosomal protein L31 -
W5S_RS24150 3490100..3490243 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
W5S_RS15740 3491002..3491370 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
W5S_RS15745 3491426..3491629 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
W5S_RS15750 3492358..3492678 + 321 WP_005976085.1 MGMT family protein -
W5S_RS15755 3492698..3493282 - 585 WP_014700819.1 YbaY family lipoprotein -
W5S_RS15760 3493493..3494356 + 864 WP_014700820.1 acyl-CoA thioesterase II -
W5S_RS15765 3494474..3495760 - 1287 WP_014700821.1 ammonium transporter AmtB -
W5S_RS15770 3495800..3496138 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T27731 WP_005976087.1 NC_017845:3491426-3491629 [Pectobacterium parmentieri]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T27731 NC_017845:3491426-3491629 [Pectobacterium parmentieri]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACGATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCCAATGATGAACTGGAGATGTTCTTTTCTGCAGCCGATCATCGCCTGGCAGAGTTGACGATGAACAAAC
TCTACGACAAAGTTCCTACCGCAGTATGGCGATACGTCCGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT27731 WP_005976089.1 NC_017845:3491002-3491370 [Pectobacterium parmentieri]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT27731 NC_017845:3491002-3491370 [Pectobacterium parmentieri]
ATGGATGAGTACACACCAAAGCATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGATGAGAGCATAGC
AACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACTTCTGCGATCAATCTCCAATTAAATGAGCTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTCTCAGAGCAGGTTGAAAAATATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGACGCTGAACTACGACGCTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACGTCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References