Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2602622..2603260 Replicon chromosome
Accession NZ_CP122604
Organism Escherichia coli strain ETEC6334

Toxin (Protein)


Gene name hicA Uniprot ID A0A3A6S5Q3
Locus tag QDW51_RS12760 Protein ID WP_063085535.1
Coordinates 2603084..2603260 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDW51_RS12755 Protein ID WP_001270286.1
Coordinates 2602622..2603038 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW51_RS12735 (2597774) 2597774..2598715 - 942 WP_063085538.1 ABC transporter permease -
QDW51_RS12740 (2598716) 2598716..2599729 - 1014 WP_063085537.1 ABC transporter ATP-binding protein -
QDW51_RS12745 (2599747) 2599747..2600892 - 1146 WP_000047450.1 ABC transporter substrate-binding protein -
QDW51_RS12750 (2601137) 2601137..2602543 - 1407 WP_282832768.1 PLP-dependent aminotransferase family protein -
QDW51_RS12755 (2602622) 2602622..2603038 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDW51_RS12760 (2603084) 2603084..2603260 - 177 WP_063085535.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDW51_RS12765 (2603482) 2603482..2603712 + 231 WP_000494244.1 YncJ family protein -
QDW51_RS12770 (2603804) 2603804..2605765 - 1962 WP_063085534.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDW51_RS12775 (2605838) 2605838..2606374 - 537 WP_000429507.1 DNA-binding transcriptional regulator SutR -
QDW51_RS12780 (2606466) 2606466..2607637 + 1172 Protein_2503 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6751.78 Da        Isoelectric Point: 11.5666

>T277306 WP_063085535.1 NZ_CP122604:c2603260-2603084 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFQGRRSVMPRHPNDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277306 WP_001270286.1 NZ_CP122604:c2603038-2602622 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6S5Q3

Antitoxin

Source ID Structure

References