Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2503705..2505293 Replicon chromosome
Accession NZ_CP122604
Organism Escherichia coli strain ETEC6334

Toxin (Protein)


Gene name hipA Uniprot ID A0A3A6RNL0
Locus tag QDW51_RS12320 Protein ID WP_063085289.1
Coordinates 2503971..2505293 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QDW51_RS12315 Protein ID WP_001296726.1
Coordinates 2503705..2503971 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDW51_RS12315 (2503705) 2503705..2503971 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDW51_RS12320 (2503971) 2503971..2505293 + 1323 WP_063085289.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDW51_RS12325 (2505696) 2505696..2506593 - 898 Protein_2412 LysR substrate-binding domain-containing protein -
QDW51_RS12330 (2506733) 2506733..2507041 + 309 WP_001221046.1 hypothetical protein -
QDW51_RS12335 (2507050) 2507050..2507739 + 690 WP_000801314.1 type 1 glutamine amidotransferase domain-containing protein -
QDW51_RS12340 (2507801) 2507801..2508748 + 948 WP_063085290.1 aldo/keto reductase -
QDW51_RS12345 (2508851) 2508851..2509006 + 156 WP_001327998.1 hypothetical protein -
QDW51_RS12350 (2508966) 2508966..2509385 + 420 WP_001314733.1 amidohydrolase family protein -
QDW51_RS12355 (2509375) 2509375..2509527 + 153 WP_001314732.1 amidohydrolase family protein -
QDW51_RS12360 (2509677) 2509677..2510248 + 572 Protein_2419 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49313.91 Da        Isoelectric Point: 8.5849

>T277305 WP_063085289.1 NZ_CP122604:2503971-2505293 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDHVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT277305 WP_001296726.1 NZ_CP122604:2503705-2503971 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A6RNL0

Antitoxin

Source ID Structure

References