Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1759881..1760434 Replicon chromosome
Accession NC_017845
Organism Pectobacterium sp. SCC3193

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3I1X4
Locus tag W5S_RS07875 Protein ID WP_014699358.1
Coordinates 1760120..1760434 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3I2T3
Locus tag W5S_RS07870 Protein ID WP_014699357.1
Coordinates 1759881..1760117 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W5S_RS07860 1756611..1757768 + 1158 WP_014699355.1 PD-(D/E)XK nuclease family protein -
W5S_RS07865 1758618..1759562 + 945 WP_014699356.1 DUF1738 domain-containing protein -
W5S_RS07870 1759881..1760117 + 237 WP_014699357.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
W5S_RS07875 1760120..1760434 + 315 WP_014699358.1 CcdB family protein Toxin
W5S_RS07880 1760965..1762219 + 1255 Protein_1563 hypothetical protein -
W5S_RS07885 1762634..1763761 + 1128 WP_014699361.1 hypothetical protein -
W5S_RS07890 1763918..1764664 - 747 WP_014699362.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1694213..1803540 109327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11545.51 Da        Isoelectric Point: 7.9859

>T27730 WP_014699358.1 NC_017845:1760120-1760434 [Pectobacterium parmentieri]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPLQTLG
AVFCDASQYRTQVKAAIDFLIDGI

Download         Length: 315 bp

>T27730 NC_017845:1760120-1760434 [Pectobacterium parmentieri]
ATGCAATTCACTGTATACGGTAATACCGGGAAAAGCGTCGTTTACCCGCTGTTGCTCGATGTCACGAGCGATATTATTGG
ACAATTGAATCGTCGGATAGTGATCCCATTGCTCCCTATTGAAAAGTATCCGGCAGGCCGCCGACCGGATCGCCTTGTCC
CCGTCGTCAGGCTGACGGACGGCAAAGAATACGCCGTAATGACGCACGAGCTGGCAAGTATTCCTCTCCAGACTCTGGGG
GCGGTGTTTTGTGATGCGTCGCAGTACCGTACTCAGGTAAAGGCCGCCATCGATTTCCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9004.06 Da        Isoelectric Point: 6.4610

>AT27730 WP_014699357.1 NC_017845:1759881-1760117 [Pectobacterium parmentieri]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRYHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT27730 NC_017845:1759881-1760117 [Pectobacterium parmentieri]
ATGACCGCGAAACAACGCAACACGCAGAGCGTGACCATGACAGTAGAGCGTGCCTTACTGGTAAGAGCGCGTGAGGCGGG
TATTAATCTGAGTGCTACCCTGACAACCGCCCTGGATGCAGAGCTTCGCTATCATGAAGCGAAAAAATGGCAAGAAGAAA
ACAGAGAGGCTCTCGCAGCACTAAATCGTTTTCATGATGAACAGGGTTGTTTCAGTGATGAATACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3I1X4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I2T3

References