Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4601355..4601852 Replicon chromosome
Accession NZ_CP122600
Organism Escherichia coli strain ETEC6333

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QDX83_RS22725 Protein ID WP_001173343.1
Coordinates 4601355..4601528 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDX83_RS22730 Protein ID WP_000398619.1
Coordinates 4601556..4601852 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX83_RS22715 (4598025) 4598025..4599482 + 1458 WP_001550473.1 dipeptide/tripeptide permease DtpC -
QDX83_RS22720 (4599719) 4599719..4601236 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDX83_RS22725 (4601355) 4601355..4601528 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QDX83_RS22730 (4601556) 4601556..4601852 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDX83_RS22735 (4602079) 4602079..4602351 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QDX83_RS22740 (4602363) 4602363..4602593 - 231 WP_001550470.1 4Fe-4S mono-cluster protein YjdI -
QDX83_RS22745 (4602773) 4602773..4604404 + 1632 WP_001216482.1 sensor histidine kinase -
QDX83_RS22750 (4604401) 4604401..4605120 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4558000..4601852 43852


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277292 WP_001173343.1 NZ_CP122600:c4601528-4601355 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277292 WP_000398619.1 NZ_CP122600:c4601852-4601556 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References